IUCN / SSC Cat Specialist Group - Digital Cat Library |
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| Barr, M.C.; Zou, L.; Holzschu, D.L.; Phillips, L.; Scott, F.W.; Casey, J.W.; Avery, R.J. | |
| Isolation of a highly cytopathic lentivirus from a nondomestic cat | |
| 1995 Journal of Virology (69): 7371-7374 | |
A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a Pallas' cat (_Otocolobus manul_) is highly cytopathic in CrFK cells, in contrast to the chronic, noncytolytic infection established by an FIV isolate from a domestic cat (FIV-Fca). The virions have typical lentivirus morphology, density, and magnesium-dependent reverse transcriptase activity. The major core protein is antigenically cross-reactive with that of FIV-Fca; however, FIV-Oma transcripts do not cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma _pol _gene has 76 to 80% nucleic acid identity with the corresponding _pol _regions of other feline lentiviruses and 64 to 69% identity with those of human, ovine, and equine lentiviruses. |
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