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Curro, T.G.; Okeson, D.; Zimmerman, D.; Armstrong, D.L.; Simmons, L.G.
Xylazine-midazolam-ketamine versus medetomidine-midazolam-ketamine anesthesia in captive Siberian tigers
2004  Journal of Zoo and Wildlife Medicine (35): 320-327

Two à2-adrenoceptor agents, xylazine and medetomidine, in combination with midazolam and ketamine safely and effectively immobilized Siberian tigers (_Panthera tigris altaica_). The medetomidine protocol used smaller drug volumes, and induction and recovery times were shorter. Although cardiopulmonary abnormalities were noted, none were likely to be life threatening.

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