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DeMott, R.P.; Suarez, S.S. | |
Evidence for an advantage of hyperactivated mouse sperm in remaining free of the oviductal wall | |
1991 Biology of Reproduction (44): 117 | |
We investigated the possibility of a functional advantage for hyperactivated mouse sperm in remaining free of the oviductal epithelium. Typically, most of the mouse sperm in the oviduct are stuck to the epithelium, but a few detach intermittently and swim freely for a short time (DeMott, R.P. and Suarez, S.S., 1990, _J _Cell Biol. 111 (5, pt. 2): abstract 2035). Hyperactivation is a vigorous, asymmetrical flagellar beating pattern mammalian sperm use near the site of fertilization in the oviduct. Several advantages have been proposed for this pattern, including an increased ability to remain free of the epithelium, increased maneuverability in the convoluted lumen of the oviduct and increased ability to move through viscous fluids. Previously, we reported that most mouse sperm are bound to the epithelium and there is a higher percentage free in the ampulla, near the site of fertilization. than the isthmus (25.9% vs. 10.8%. DeMott and Suarez, 1990). We have also observed that many of the sperm within the oviductal lumen, especially the free sperm, appear hyperactivated. |
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