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Stanton, J.B.; Givens, L.; Evermann, J.F.; Brown, C.C.
Immunohistochemical Analysis of Two Strains of Lion (_Panthera leo_)-adapted Canine Distemper Virus in Ferrets (_Mustela putorius furo_)
2003 Veterinary Pathology (40): 464-467
Canine distemper virus (CDV) caused epizootics in lions (Panthera leo) in Tanzanias Serengeti National Park in 1994 and in captive lions and other Panthera spp. in the USA in 1991-1992. In this study, immunohistochemistry was used to compare viral distrubution in tissues collected from ferrets (Mustela putorius furo) inoculated with one of the two lion-derived CDV istolates, either from Serengeti (A94-11/13) or from California (A92-27/20). The California isolate resulted in severe morbidity in all nine ferrets, whereas the Serengeti isolate resulted in severe morbidity in five of the nine ferrets. A slightly higher proportion of infected cells was found in many tissues in the Serengeti isolate-inoculated ferrets. These findings indicate that the pathogenicity of the California isolate is not directly related to the number of infected cells.
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