IUCN / SSC Cat Specialist Group - Digital Cat Library |
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| Jim‚nez, M.A.; S nchez, B.; Garcˇa, P.; P‚rez, M.D.; Carrillo, M.E.; Moreno, F.J.; Pe¤a, L. | |
| Diseases of the Iberian lynx (_Lynx pardinus_): histopathological survey, lymphoid depletion, glomerulonephritis and related clinical findings (Enfermedades del lince ib‚rico (_Lynx pardinus_): estudio histopatol˘gico, depleci˘n linfoide, glomerulonefritis y hallazgos clˇnicos relacionados) | |
| 2009 Book Chapter | |
A research study was conducted, between the years 1998-2006, which involved thorough post-mortem and histological evaluations of Iberian lynxes from the two remaining, populations of Do¤ana National Park and Sierra Morena. Initial studies revealed lymphoid depletion, glomerulonephritis and splenic follicular hyalinosis among other less frequent findings such as tuberculosis and squamous cell carcinomas. Formalin fixed tissue samples of all organ systems from 40 Iberian lynxes were routinely processed, stained with hematoxilin-eosin and evaluated. Additionally, special stains, immunohistochemistry and electron microscopy were applied on renal and lymphoid tissues of selected cases. The immunity status was evaluated by means of lymphoproliferative stimulation and phenotyping of peripheral blood mononuclear cell types using whole blood samples from 23 Iberian lynxes. Blood (n=23) and urine (n=17) samples were prospectively collected for evaluation of renal function. Various degrees of both B and T cells depletion in peripheral lymphoid tissues were noted in the majority of animals. Lymphoproliferative assays and flow cytometry also revealed diminished responses and decreased numbers of lymphocytes respectively in the majority of animals. Dense hyaline material was noted in many of the spleens evaluated. Different stages of membranous glomerulonephritis (MGN) were present in all of the animals. Sixteen of the 23 live animals evaluated also contained some signs of chronic renal disease. Renal impairment and immunity alterations may impact conservation management of the surviving populations and should be considered. |
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